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September 8, 2025

Does Meloxicam Cause Weight Gain?

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Last Medical Review on: September 8, 2025
Last Updated On: Oct. 7, 2025
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Medically Reviewed by Dr. Faith A. Coleman, M.D.
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    Key Points

    • Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that is prescribed to treat different types of arthritis.
    • Meloxicam is effective for relieving the pain and inflammation that accompany many types of arthritis.
    • Meloxicam can cause weight gain and weight loss, but it is a rare side effect.
    • Fluid retention can lead to weight gain in people who take meloxicam.
    • If you’re gaining weight while on meloxicam, you can try eating a healthy diet, staying hydrated, and getting plenty of exercise to manage your weight.
    • More common side effects of taking meloxicam include diarrhea, indigestion, and dizziness.

    Meloxicam is a prescription medication used to treat different types of arthritis. [1] While it can be successful in doing so, it can also cause some people to experience side effects. These side effects can include weight gain. If you’ve been prescribed meloxicam or are considering taking it to treat your arthritis, it’s helpful to know how it may impact your weight and to be aware of other potential side effects.

    Can Meloxicam Cause Changes in Body Weight?

    Meloxicam can cause both increases and decreases in body weight. Clinical studies, however, have shown that this is a rare side effect of taking the medication. [2] Studies show that gaining or losing weight as a result of taking Meloxicam occurs in less than 2% of people taking the drug. [3] 

    What is Meloxicam?

    Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that is prescribed to treat different types of arthritis, such as: [4]

    • Osteoarthritis
    • Rheumatoid Arthritis
    • Juvenile Rheumatoid Arthritis

    It works to treat the inflammation, swelling, stiffness, and joint pain that these conditions can cause. It is available in a tablet, suspension, capsule, or disintegrating tablet form. Meloxicam is sold under the brand name Mobic.

    What are the Benefits of Taking Meloxicam?

    Meloxicam is effective for relieving the pain and inflammation that accompany many types of arthritis. This medication is unlikely to lead to dependence and is easy to take, with or without food. 

    What Can Lead to Weight Changes When Taking Meloxicam?

    There are several reasons why you might see changes in your weight while taking meloxicam. Each person’s genetic makeup will lead to variations in the physical response to this medication, but some common weight changes may include the following.

    Fluid Retention

    People who take meloxicam have a greater chance of retaining fluid. [5]  When people retain fluid, they can see the weight on the scale increase. It is essential to treat fluid retention quickly because if left untreated, it can lead to heart failure..

    Appetite Changes

    Changes in appetite can occur while taking meloxicam. Some people may have a bigger appetite, while others experience a loss of appetite. Both of these can influence weight. [6]

    Changes in Metabolism

    Some people who take meloxicam can see metabolic changes that can impact weight. If your metabolism is not working so quickly, you may see weight gain.

    Increased Activity Level

    While some people may see their metabolism slow down while taking the drug, others may have an increased activity level as their pain decreases. Using more energy means burning more calories. This can result in weight loss.

    How to Avoid Weight Gain While Taking Meloxicam

    Man and woman standing on scales.

    If you’ve noticed that you’re gaining weight while taking meloxicam, there are some things you can do to control it. 

    • Managing your portion size and getting enough exercise are key.
    • Eat a healthy diet full of fruits, vegetables, and protein.
    • Drink water and avoid sugary drinks.
    • Avoid processed and sugary foods.

    If you’ve implemented these changes into your routine and weight is still an issue while on meloxicam, you’ll want to talk to a healthcare professional.

    Common Side Effects of Meloxicam

    While weight gain and weight loss are not common side effects of meloxicam, there are several more common side effects you’ll want to be aware of if you’re taking the drug or considering it. [7]

    • Diarrhea
    • Fever
    • Sore Throat
    • Flu-Like Symptoms
    • Upper Respiratory Tract Infections
    • Indigestion
    • Drowsiness
    • Abdominal Pain
    • Back Pain
    • Dizziness
    • Insomnia
    • Gastrointestinal Issues
    • Skin Reactions
    • Allergic Reactions

    These side effects are typically mild. There are more serious side effects you’ll want to watch for if you are taking this drug, such as: [8]

    • Low red blood cell level
    • Swelling of the face, arms, or legs
    • High blood potassium level
    • Liver Problems and Liver Failure
    • Kidney Problems and Kidney Failure
    • Severe Allergic Reaction
    • Serious Digestive System Problems

    If you think you are experiencing a more serious side effect due to taking meloxicam, contact the prescriber for instructions..

    Are There Long-Term Side Effects of Meloxicam?

    People taking meloxicam can experience long-term side effects. These can occur any time you’re taking the drug or may not go away even if you stop taking it.

    Studies have shown several long-term side effects of taking meloxicam, listed in a boxed warning, the most serious FDA warning a drug can carry, and includes: [9]

    These include:

    Serious cardiovascular side effects

    • People who have taken meloxicam carry a greater risk of developing a heart attack and stroke due to taking the drug.
    • Anyone undergoing heart bypass surgery or who has had a recent heart attack may experience cardiovascular side effects
    • High cholesterol or tobacco use also increases the risk of cardiovascular side effects..

    Serious gastrointestinal side effects like ulcers, holes in your digestive tract, and internal bleeding

    • Those who have had a peptic ulcer in the past or who currently have one have an increased risk of serious gastrointestinal side effects.
    • People who are actively bleeding in their digestive tract or have had in the past can also be in danger.
    • Being 65 and older can play a role, as well as tobacco or alcohol use.

    If you fall under any of these categories, you’ll want to talk to your doctor before taking meloxicam. They can determine if the risks are worth taking the drug for its intended use.

    Learn More About Meloxicam & Its Side Effects

    If you or a loved one is taking meloxicam, and you want to know whether meloxicam causes weight gain or weight loss, help is available. Seek all the answers you need to make an informed decision about your healthcare.

    Frequently Asked Questions About Does Meloxicam Cause Weight Gain

    Can I take meloxicam if I’m pregnant or breastfeeding?

    It is not recommended to take Meloxicam from the 20th week of pregnancy and beyond. [10] There are potential risks to the developing baby. It is also not recommended to take meloxicam while breastfeeding so that the medication does not pass through the breastmilk.

    What should you avoid when taking meloxicam?

    Don’t take alcohol, blood thinners, or other NSAIDs when taking meloxicam. [11] Taking meloxicam with other NSAIDs can increase your risk for stomach ulcers and bleeding. Antidepressants and certain blood pressure medications are also known not to interact well.

    What foods should you not eat with meloxicam?

    It’s advised to avoid grapefruit juice or foods containing grapefruit while taking meloxicam. Side effects of the medication can get worse when you combine the two. [12]

    Are the side effects of meloxicam different for children?

    Children with juvenile idiopathic arthritis are often prescribed meloxicam. [13] Side effects such as abdominal pain, fever, diarrhea, and headache are usually more common in children than in adults taking the medication.

    Can you overdose on meloxicam?

    It is possible to overdose on meloxicam. Symptoms of overdose include: [14]

    • Nausea
    • Vomiting
    • Stomach Pain
    • Drowsiness
    • Seizures
    • Difficulty Breathing
    • Bloody or black stools
    • Coma

    In case of overdose,  seek emergency treatment by calling 911.

    What should I do if I forget a dose?

    If you forget a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and continue on your regular schedule. Never take a double dose to make up for the missed one. [15]

    Are there any precautions I should take before starting meloxicam?

    Before taking meloxicam, be sure to tell your doctor if you have any allergies to aspirin or NSAIDs like ibuprofen and naproxen. Asking for a list of meloxicam ingredients is a good idea if you’re worried about allergies.

    If you’ve ever had asthma, be sure your doctor knows. This is especially important if you have nasal polyps or swelling of the hands, feet, or ankles. If you’re having surgery, be sure to tell your doctor you are taking meloxicam. [16]

    People with fructose intolerance should also be careful because the oral suspension of meloxicam is sweetened with sorbitol.

    Sources

    [1] [7] [8] [13] Meloxicam oral tablet side effects. Optum Perks. (n.d.). Retrieved from https://perks.optum.com/blog/meloxicam-oral-tablet-side-effects on August 12, 2025.

    [2] [9] These highlights do not include all the information needed to use pantoprazole sodium delayed-release tablets safely and effectively. see full prescribing information for pantoprazole sodium delayed-release tablets. (n.d.-k). Retrieved from https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/f38a6df2-1dd4-48bf-9ec4-1113ce492e78/spl-doc on August 12, 2025.

    [3] 3928101 1 this label may not be the latest approved by FDA … (n.d.-c). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020938s024s025,021530s014s015lbl.pdf on August 12, 2025.

    [4] Mayo Foundation for Medical Education and Research. (n.d.-b). Meloxicam (oral route). Mayo Clinic. Retrieved from https://www.mayoclinic.org/drugs-supplements/meloxicam-oral-route/description/drg-20066928 on August 12, 2025.

    [5] U.S. National Library of Medicine. (n.d.-a). Meloxicam. National Center for Biotechnology Information. PubChem Compound Database. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Meloxicam#section=Drug-Classes on August 12, 2025.

    [6] Meloxicam side effects: Common, severe, long term. Drugs.com. (n.d.-g). Retrieved from https://www.drugs.com/sfx/meloxicam-side-effects.html on August 12, 2025.

    [10] Meloxicam use during pregnancy. Drugs.com. (n.d.-h). Retrieved from https://www.drugs.com/pregnancy/meloxicam.html#:~:text=Contraindicated%20last%20trimester%20of%20pregnancy,dose%20(MRHD)%2C%20respectively on August 12, 2025.

    [11] 7 meloxicam interactions you should know about – goodrx. (n.d.-a). Retrieved from https://www.goodrx.com/meloxicam/interactions on August 12, 2025.

    [12] Meloxicam or mobic: Food, alcohol, supplements and drug interactions. (n.d.-j). Retrived from https://www.wellrx.com/meloxicam/lifestyle-interactions/ on August 12, 2025.

    [14] [15] [16] U.S. National Library of Medicine. (n.d.-d). Meloxicam: Medlineplus Drug Information. MedlinePlus. Retrieved from https://medlineplus.gov/druginfo/meds/a601242.html#:~:text=In%20case%20of%20emergency/overdose,Expand%20Section on August 12, 2025.